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MINI-FOCUS: INFLAMMATION IN CARDIAC INJURY The IL-1b Antibody Gevokizumab Limits Cardiac Remodeling and Coronary Dysfunction in Rats With Heart Failure

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Harouki, Najah | Nicol, Lionel | Remy-Jouet, Isabelle | Henry, Jean-Paul | Dumesnil, Anaïs | Lejeune, Annie | Renet, Sylvanie | Golding, Francesca | Djerada, Zoubir | Wecker, Didier | Bolduc, Virginie | Bouly, Muriel | Roussel, Jérôme | Richard, Vincent | Mulder, Paul

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International audience. HIGHLIGHTS Immediate IL-1b antibody gevokizumab administration reduces ischemia/ reperfusion related infarct size. Immediate and late IL-1b antibody gevokizumab administration improves heart failure related left ventricular remodeling. IL-1b antibody gevokizumab improves heart failure related coronary dysfunction. From

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