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Viral manipulation of STAT3: Evade, exploit, and injure

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Roca Suarez, Armando Andres | van Renne, Nicolaas | Baumert, Thomas, F | Lupberger, Joachim

Edité par CCSD ; Public Library of Science -

International audience. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of numerous physiological functions, including the immune response. As pathogens elicit an acute phase response with concerted activation of STAT3, they are confronted with two evolutionary options: either curtail it or employ it. This has important consequences for the host, since abnormal STAT3 function is associated with cancer development and other diseases. This review provides a comprehensive outline of how human viruses cope with STAT3-mediated inflammation and how this affects the host. Finally, we discuss STAT3 as a potential target for antiviral therapy.

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