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Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

Archive ouverte | Marín, Eros | CCSD

International audience. Cell therapy is a promising strategy for treating patients suffering from autoimmune or inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have generated hu...

Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4 + T cells

Archive ouverte | Lancien, Mélanie | CCSD

Intracellular ion fluxes emerge as critical actors of immunoregulation but still remain poorly explored. Here we investigated the role of the redundant cation channels TMEM176A and TMEM176B (TMEM176A/B) in RORγt + cells and conven...

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4 + T Cells

Archive ouverte | Lancien, Melanie | CCSD

International audience. Intracellular ion fluxes emerge as critical actors of immunoregulation but still remain poorly explored. In this study, we investigated the role of the redundant cation channels TMEM176A and ...

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