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Expanded human CD8+CD45RClowFoxp3+ Tregs secreting IFNγ, IL-10, IL-34 and TGFβinhibit human transplant rejection

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Bézie, Séverine | Meistermann, Dimitri | Boucault, Laetitia | Kilens, Stephanie | Zoppi, Johanna | Autrusseau, Elodie | Donnart, Audrey | Daguin, Véronique | Bellier-Waast, Frédérique | Charpentier, Eric | Duteille, Franck | David, Laurent | Anegon, Ignacio | Guillonneau, Carole

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International audience. Tregs play a critical role in the control of immune responses and tolerance induction; however our understanding of CD8+ Tregs is limited while they are particularly promising for therapeutic application. We previously reported that CD8+CD45RC[low] Tregs use IFNγ and IL-34 to suppress donor responses in a rat model of allotransplantation (Guillonneau et al, JCI, 2007 ; Bezieetal, JCI, 2015). Here, we aim to characterize human CD8+ Tregs to assess their potential for cell therapy in transplantation in comparison to CD4+CD25[high]CD127- Tregs .

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