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Alteration of CD8+ CD45RC[int/neg] regulatory T cells functions in Multiple Sclerosis and correlates with disease severity

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Benallegue, Naïl | Nicol, Bryan | Bézie, Séverine | Regue, Hadrien | Vimont, Nadège | Flippe, Léa | Garcia, Alexandra | Laplaud, David, A. | Guillonneau, Carole

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Naïl Benallegue, Bryan Nicol, David A. Laplaud and Carole Guillonneau are co-authors.. International audience. Autoimmune diseases can develop following pathological activation of autoreactive effector cells and/or, alternatively, after weakening of self-protective regulatory mechanisms. Most of the studies have focused on CD4+ Tregs and the role of CD8+ Tregs in Multiple Sclerosis (MS) remains largely unexplored. We previously reported the suppressive properties of rat and human CD8+CD45RCint/neg Treg cells, expressing Foxp3 and acting through IFNg, TGFb and IL34 cytokines (Guillonneau, JCI, 2007; Bézie, JCI, 2015, Bézie, Front. Immunol., 2018). Thus, their potency of suppression make them strong candidates of disruptive immune tolerance, especially in MS where CD8+ T cells play a major role. Thus, the overreaching goal of this study is to define the role of CD8+ regulatory T cell in MS pathogenesis.

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