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IL-34 is a Treg-specific cytokine and mediates transplant tolerance

Archive ouverte | Bézie, Séverine | CCSD

International audience. Cytokines and metabolic pathway-controlling enzymes regulate immune responses and have potential as powerful tools to mediate immune tolerance. Blockade of the interaction between CD40 and CD...

Cross-Reactive Donor-Specific CD8+ Tregs Efficiently Prevent Transplant Rejection

Archive ouverte | Picarda, Elodie | CCSD

International audience. To reduce the use of non-specific immunosuppressive drugs detrimental to transplant patient health, therapies in development aim to achieve antigen-specific tolerance by promoting antigen-spe...

Compensatory Regulatory Networks between CD8 T, B, and Myeloid Cells in Organ Transplantation Tolerance

Archive ouverte | Bézie, Séverine | CCSD

International audience. In transplantation tolerance, numerous regulatory populations have the capacity to inhibit allograft rejection; however, their compensatory capacities have never been clearly evidenced. We ha...

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