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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

Archive ouverte | Hoguet, Vanessa | CCSD

International audience. PEGylation of therapeutic agents is known to improve the pharmacokinetic behavior of macromolecular drugs and nanoparticles. In this work, we performed the conjugation of polyethylene glycols...

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Archive ouverte | Déprez-Poulain, Rebecca | CCSD

International audience. Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's disease and type-...

Identification of indole-based activators of insulin degrading enzyme

Archive ouverte | Kraupner, Nicolas | CCSD

International audience. Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 d...

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