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Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways

Archive ouverte | Tessoulin, Benoit | CCSD

International audience. Background: Human myeloma cell lines (HMCLs) are widely used for their representation of primary myeloma cells because they cover patient diversity, although not fully. Their genetic backgrou...

Dual targeting of BCL2 and MCL1 rescues myeloma cells resistant to BCL2 and MCL1 inhibitors associated with the formation of BAX/ BAK hetero-complexes

Archive ouverte | Seiller, Carolane | CCSD

International audience. Multiple myeloma is a plasma cell malignancy that escapes from apoptosis by heterogeneously over-expressing anti-apoptotic BCL2 proteins. Myeloma cells with a t(11;14) translocation present a...

VDAC2 primes myeloma cells for BAK-dependent apoptosis and represents a novel therapeutic target

Archive ouverte | Champion, Ophélie | CCSD

International audience

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