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Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma

Archive ouverte | Gaudelot, Kelly | CCSD

International audience. Renal cell carcinoma, the most common neoplasm of adult kidney, accounts for about 3% of adult malignancies and is usually highly resistant to conventional therapy. MicroRNAs are a class of s...

A Double-Negative Feedback Interaction between miR-21 and PPAR-α in Clear Renal Cell Carcinoma

Archive ouverte | Goujon, Marine | CCSD

International audience. Clear cell renal cell carcinoma (ccRCC) is the main histotype of kidney cancer, which is typically highly resistant to conventional therapies and known for abnormal lipid accumulation. In thi...

Role of the MUC1 mucin in non tumoral kidney diseases. Rôle de la mucine MUC1 en pathologie rénale non tumorale

Archive ouverte | Gibier, Jean-Baptiste | CCSD

MUC1 is a glycoprotein expressed in the distal and collecting tubes of the adult kidney. Inrenal diseases, it is mainly known to be expressed in certain renal carcinomas and alsobecause mutations in the MUC1 gene are responsible f...

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