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The infectious hypoxia: occurrence and causes during Shigella infection

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Arena, Ellen, T | Tinevez, Jean-Yves | Nigro, Giulia, S | Sansonetti, Philippe | Marteyn, Benoit, S

Edité par CCSD ; Elsevier -

EA and J-YT contributed equally to this work . International audience. Hypoxia is defined as a tissue oxygenation status below physiological needs. During Shigella infection, an infectious hypoxia is induced within foci of infection. In this review, we discuss how Shigella physiology and virulence are modulated and how the main recruited immune cells, the neutrophils, adapt to this environment.

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