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Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

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Kurbatova, Polina | Wendling, Fabrice | Kaminska, Anna | Rosati, Anna | Nabbout, Rima | Guerrini, Renzo | Dulac, Olivier | Pons, Gérard | Cornu, Catherine | Nony, Patrice | Chiron, Catherine | Benquet, Pascal

Edité par CCSD ; Elsevier -

International audience. Highlights x Excitatory GABA effect was implemented in a computational neural mass model x Dynamic emergence of depolarizing GABA triggers interictal to ictal transitions x Results suggest a major role of GABAergic interneurons in seizure onset x Model reproduces clinical patterns found in a severe infantile epilepsy

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