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Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

Archive ouverte | Lopez-Atalaya, José P. | CCSD

International audience. Background and Purpose—Desmoteplase, a recombinant form of the plasminogen activator DSPAα1 from Desmodus rotundus, may offer improved clinical benefits for acute ischemic stroke treatment ov...

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator.

Archive ouverte | Roussel, Benoit, D | CCSD

International audience. Owing to its ability to generate the clot-dissolving protease plasmin, tissue plasminogen activator (tPA) is the only approved drug for the acute treatment of ischemic stroke. However, tPA al...

Normalization of Reverse Transcription Quantitative PCR Data During Ageing in Distinct Cerebral Structures

Archive ouverte | Bruckert, Geoffrey | CCSD

International audience. Reverse transcription quantitative-polymerase chain reaction (RT-qPCR) has become a routine method in many laboratories. Normalization of data from experimental conditions is critical for dat...

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