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Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes using monoclonal antibodies.

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Fofana, Isabel | Zona, Laetitia | Thumann, Christine | Heydmann, Laura | Durand, Sarah, C. | Lupberger, Joachim | Blum, Hubert, E. | Pessaux, Patrick | Gondeau, Claire | Reynolds, Gary, M. | Mckeating, Jane, A. | Grunert, Fritz | Thompson, John | Zeisel, Mirjam, B. | Baumert, Thomas, F.

Edité par CCSD ; American Society for Microbiology -

International audience. : The relevance of claudin-6 and claudin-9 in hepatitis C virus (HCV) entry remains elusive. We produced claudin-6 or claudin-9 specific monoclonal antibodies that inhibit HCV entry into non-hepatic cells expressing exogenous claudin-6 or claudin-9. These antibodies had no effect on HCV infection of hepatoma cells or primary hepatocytes. Thus although claudin-6 and claudin-9 can serve as entry factors in cell lines, HCV infection into human hepatocytes is not dependent on claudin-6 and claudin-9.

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