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Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

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Chartrel, Nicolas | Alvear-Perez, Rodrigo | Leprince, Jérôme | Iturrioz, Xavier | Reaux-Le Goazigo, Annabelle | Audinot, Valérie | Chomarat, Pascale | Cogé, Francis | Nosjean, Olivier | Rodriguez, Marianne | Galizzi, Jean-Pierre | Boutin, Jean, A. | Vaudry, Hubert | Llorens-Cortes, Catherine

Edité par CCSD ; American Association for the Advancement of Science (AAAS) -

International audience. Zhang et al. (Research Articles, 11 November 2005, p. 996) reported that obestatin, a peptide derived from the ghrelin precursor, activated the orphan G protein-coupled receptor GPR39. However, we found that I125-obestatin does not bind GPR39 and observed no effects of obestatin on GPR39-transfected cells in various functional assays (cyclic adenosine monophosphate production, calcium mobilization, and GPR39 internalization). Our results indicate that obestatin is not the cognate ligand for GPR39.

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