Afficher la couverture '[Therapeutic agents targetting protein-protein interactions: myth or reality?] | Laudet, Béatrice' en grand format
/5

0 avis

[Therapeutic agents targetting protein-protein interactions: myth or reality?]

Archive ouverte

Laudet, Béatrice | Prudent, Renaud | Filhol, Odile | Cochet, Claude

Edité par CCSD ; EDP Sciences -

International audience. Protein-protein interactions have a key role in transduction pathways that regulate many cellular functions. Structural and functional properties of protein-protein interface are now better understood, therefore offering attractive opportunities for therapeutic intervention. Developping small molecules that modulate protein-protein interactions is challenging. Nethertheless, significant progress in this endeavour has been made on several fronts. Here, we use few illustrative examples to summarize recent work in this emerging field.

Consulter en ligne

Suggestions

Du même auteur

Structure-based design of small peptide inhibitors of protein-kinase CK2 subunit interaction

Archive ouverte | Laudet, Béatrice | CCSD

International audience. X-ray crystallography studies as well as live-cell fluorescent imaging have recently challenged the traditional view of Protein-kinase CK2. Unbalanced expression of catalytic and regulatory C...

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Archive ouverte | Kufareva, Irina | CCSD

International audience. CK2 is a constitutively active protein kinase overexpressed in numerous malignancies. Interaction between CK2α and CK2β subunits is essential for substrate selectivity. The CK2α/CK2β interfac...

Identification of chemical inhibitors of protein-kinase CK2 subunit interaction.

Archive ouverte | Laudet, Béatrice | CCSD

International audience. Protein kinase CK2 is a multi-subunit complex whose dynamic assembly appears as a crucial point of regulation. The ability to interfere with specific protein-protein interactions has already ...

Chargement des enrichissements...