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In Vitro Phenotypic Susceptibility of Human Immunodeficiency Virus Type 2 Clinical Isolates to Protease Inhibitors.

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Desbois, Delphine | Roquebert, Bénédicte | Peytavin, Gilles | Damond, Florence | Collin, Gilles | Bénard, Antoine | Campa, Pauline | Matheron, Sophie | Chêne, Geneviève | Brun-Vézinet, Francoise | Descamps, Diane | Anrs Hiv-2 Cohort, French

Edité par CCSD ; American Society for Microbiology -

International audience. We determine phenotypic susceptibility of human immunodeficiency virus type 2 (HIV-2) isolates to amprenavir, atazanavir, darunavir, indinavir, lopinavir, nelfinavir, saquinavir, and tipranavir. Saquinavir, lopinavir, and darunavir are potent against wild-type HIV-2 isolates and should be preferred as first-line options for HIV-2-infected patients. Other protease inhibitors are less active against HIV-2 than against HIV-1.

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