[Cranberry (Vaccinium macrocarpon) and urinary tract infections: study model and review of literature]

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Lavigne, Jean-Philippe | Bourg, G. | Botto, Henri | Sotto, Albert

Edité par CCSD ; Elsevier Masson -

International audience. Cranberries (Vaccinium macrocarpon) have long been the focus of interest for their beneficial effects in preventing urinary tract infections. Among cranberry compounds, a group of proanthocyanidins (PACs) with A-type linkages were isolated which exhibit bacterial anti-adhesion activity against uropathogenic Escherichia coli strains. These PAC inhibit P-fimbriae synthesis and induce a bacterial deformation. This activity was demonstrated on both antibiotic susceptible and resistant bacteria. This review focused on the last discoveries in the knowledge of cranberry effects.

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