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Increased risk of essential tremor in first-degree relatives of patients with Parkinson's disease.

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Rocca, Walter, A. | Bower, James, H. | Ahlskog, J. Eric | Elbaz, Alexis | Grossardt, Brandon, R. | Mcdonnell, Shannon, K. | Schaid, Daniel, J. | Maraganore, Demetrius, M.

Edité par CCSD ; Wiley -

International audience. We conducted a historical cohort study of 981 first-degree relatives of 162 patients with Parkinson's disease (PD) and of 838 first-degree relatives of 147 controls representative of the population of Olmsted County, Minnesota. In addition, we studied 2,684 first-degree relatives of 411 patients with PD referred to the Mayo Clinic. Relatives were interviewed and screened for tremor either directly or through a proxy, and those who screened positive were examined or copies of their medical records were obtained to confirm the diagnosis of essential tremor (ET). We also obtained ET information from a medical records-linkage system (family study method). In the population-based sample, the risk of ET was significantly increased for relatives of patients with onset of PD

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