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Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?

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Méhats, Céline | Schmitz, Thomas | Breuiller-Fouché, Michelle | Leroy, Marie-Josèphe | Cabrol, Dominique

Edité par CCSD ; Elsevier -

International audience. Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.

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