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Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.. Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.: Tuberculosis on antiretroviral therapy

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Brinkhof, Martin, W.G. | Egger, Matthias | Boulle, Andrew | May, Margaret | Hosseinipour, Mina | Sprinz, Eduardo | Braitstein, Paula | Dabis, Francois | Reiss, Peter | Bangsberg, David, R. | Rickenbach, Martin | Miro, Jose, M. | Myer, Landon | Mocroft, Amanda | Nash, Denis | Keiser, Olivia | Pascoe, Margaret | van Der Borght, Stefaan | Schechter, Mauro

Edité par CCSD ; Oxford University Press (OUP) -

International audience. We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.

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