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The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and betaarrestin

Archive ouverte | Armando, Sylvain | CCSD

International audience. G-protein-coupled receptors have been shown to assemble at least as dimers early in the biosynthetic path, but some evidence suggests that they can also form larger oligomeric complexes. Usin...

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.

Archive ouverte | Ferré, Sergi | CCSD

International audience. Most evidence indicates that, as for family C G protein-coupled receptors (GPCRs), family A GPCRs form homo- and heteromers. Homodimers seem to be a predominant species, with potential dynami...

Beta-arrestins operate an on/off control switch for Focal Adhesion Kinase activity

Archive ouverte | Alexander, Revu, Ann | CCSD

International audience. Focal adhesion kinase (FAK) regulates key biological processes downstream of G protein-coupled receptors (GPCRs) in normal and cancer cells, but the modes of kinase activation by these recept...

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