Effet de la fonctionnalisation de surface des nanoparticules sur leur internalisation et sur les dommages causés à l'ADN

Archive ouverte | Dekali, Samir | CCSD

Specific uptake and genotoxicity induced by polystyrene nanobeads with distinct surface chemistry on human lung epithelial cells and macrophages

Archive ouverte | Paget, Vincent | CCSD

International audience. Nanoparticle surface chemistry is known to play a crucial role in interactions with cells and their related cytotoxic effects. As inhalation is a major route of exposure to nanoparticles, we ...

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

Archive ouverte | Schellenbauer, Amelie | CCSD

International audience. Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-se...