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Archive ouverte | Onana, Denis Fils Nkoa | CCSD

International audience. HIV viral blips are characterized by intermittent episodes of detectable low-level viraemia which return spontaneously to an undetectable level in patients with full suppression of viraemia ....

How Molecular Should Your Molecular Model Be? : On the Level of Molecular Detail Required to Simulate Biological Networks in Systems and Synthetic Biology

Archive ouverte | Gonze, Didier | CCSD

The recent advance of genetic studies and the rapid accumulation of molecular data, together with the increasing performance of computers, led researchers to design more and more detailed mathematical models of biological systems....

Kinetic modelling of in vitro cell-based assays to characterize non-specific bindings and ADME processes in a static and a perfused fluidic system

Archive ouverte | Ouattara, Djomangan Adama | CCSD

International audience. Recently, physiologically based perfusion in vitro systems have been developed to provide cell culture environment close to in vivo cell environment (e.g., fluidic conditions, organ interacti...

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