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Plasma triacylglycerols are biomarkers of (3-cell function in mice and humans

Archive ouverte | Sanchez-Archidona, Ana Rodriguez | CCSD

International audience. Objectives: To find plasma biomarkers prognostic of type 2 diabetes, which could also inform on pancreatic (3-cell deregulations or defects in the function of insulin target tissues. Methods:...

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

Archive ouverte | Wigger, Leonore | CCSD

International audience. Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma ...

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion

Archive ouverte | Cruciani-Guglielmacci, Céline | CCSD

International audience. ObjectiveIn type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes in...

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