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In Vivo Comparison of Two Injectable Calcium Phosphate Biomaterials: Ionic Cement and Polymer-Associated Particulate Ceramic
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Edité par CCSD ; Trans Tech Publications -
International audience. The present study compared the in vivo behavior of an ionic calcium phosphate bone cement and an composite injectable bone substitute (IBS) associating a biphasic calcium phosphate (BCP) mineral phase and a cellulosic polymer. Three weeks after implantation in rabbit bone, both biomaterials expressed biocompatibility and bioactivity but new bone formation and ceramic degradadation were significantly higher for IBS than for the tested ionic cement. With IBS, newly-formed bone developed joining the BCP particles the ones to the others whereas new bone only grew on the surface of the cement that remained dense with no obvious degradation 3 weeks after implantation. This study confirms that BCP particles carried by a cellulosic polymer can conserve bioactivity and are conducive to earlier and more extensive bone substitution than a carbonated-HA bone cement. The presence of intergranular spaces in the IBS seemed particularly favorable since each BCP granule can be reached by body fluids immediately after implantation. Thus, the IBS seemed to function as a completely interconnected ceramic with total open macroporosity.
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