Risk factors for cerebral palsy and movement difficulties in 5-year-old children born extremely preterm
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Aubert, Adrien, M | Costa, Raquel | Johnson, Samantha | Ådén, Ulrika | Cuttini, Marina | Koopman-Esseboom, Corine | Lebeer, Jo | Varendi, Heili | Zemlin, Michael | Pierrat, Véronique | Zeitlin, Jennifer | Lebeer, J. | van Reempts, P. | Bruneel, E. | Cloet, E. | Oostra, A. | Ortibus, E. | Sarrechia, I. | Boerch, K. | Pedersen, P. | Toome, L. | Männamaa, M. | Ancel, P, Y | Burguet, A. | Jarreau, P, H | Truffert, P. | Maier, R, F | Misselwitz, B. | Wohlers, L. | Croci, I. | Carnielli, V. | Ancora, G. | Faldella, G. | Ferrari, F. | van Heijst, A. | Gadzinowski, J. | Mazela, J. | Montgomery, A. | Pikuła, T. | Barros, H. | Rodrigues, C. | Draper, E, S | Fenton, A. | Mader, S. | Thiele, N. | Pfeil, J, M | Petrou, S. | Kim, S, W | Andronis, L. | Bonnet, C. | El Rafei, R. | Seppänen, A, V
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BackgroundMotor impairment is common after extremely preterm (EPT, 15th percentile) among five-year-old children.ResultsCompared to children without MD (n=366), young maternal age, male sex and bronchopulmonary dysplasia were similarly associated with CP (n=100) and non-CP MD (n=224) with Relative Risk Ratios (RRR) ranging from 2.3 to 3.6. CP was strongly related to severe brain lesions (>10), other neonatal morbidities, congenital anomalies and low Apgar score (RRR: 2.4 to 3.3), while non-CP MD was associated with primiparity, maternal education, small for GA (RRR: 1.6 to 2.6) and severe brain lesions, but at a much lower order of magnitude.ConclusionCP and non-CP MD have different risk factor profiles, with fewer clinical but more sociodemographic risk factors for non-CP MD.
