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Development of a pediatric oral solution of ONC201 using nicotinamide to enhance solubility and stability

Archive ouverte | Annereau, Maxime | CCSD

International audience. Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood–brain barrier with effe...

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Archive ouverte | Cerveto, Thomas | CCSD

The long-standing issue of inadequate medicine formulations has been a focus of regulatory bodies and pharmaceutical research, particularly in adapting medicines for children’s unique requirements. The pediatric population present...

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Archive ouverte | Annereau, Maxime | CCSD

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