0 avis
Genomic Diversity and Zoonotic Potential of Brucella neotomae
Archive ouverte
Edité par CCSD ; Centers for Disease Control and Prevention -
International audience. The genus Brucella comprises a monophyletic group including 6 classical species showing clonal evolution: B. abortus, B. suis, B. melitensis, B. canis, B. ovis, and B. neotomae (1,2). The zoonotic potential of B. melitensis, B. abortus, B. suis, and B. canis (in decreasing order of disease burden in human populations) has been clinically established on the basis of numerous human cases reported over the past century. B. neotomae was originally isolated from a single rodent species (desert woodrat, Neotoma lepida), in an area with low population density of other wild animals and remote from domestic livestock (3). Recently, 2 publications described the isolation in Costa Rica of B. neotomae strains from 2 human patients with brucellosis (4,5). According to those reports, the 2 human isolates, bneohCR1 and bneohCR2, differed from each other by 164 singlenucleotide polymorphisms (SNPs); bneohCR1 differed from the B. neotomae genome used as reference in the analysis (GenBank accession no. GCA_000742255) by 174 and bneohCR2 by 160 SNPs. Those data indicated that B. neotomae has zoonotic potential and is present in a much wider geographic area than previously reported.
Consulter en ligne
Suggestions
Du même auteur
