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Value of peri-operative chemotherapy in patients with CINSARC high-risk localized grade 1 or 2 soft tissue sarcoma: study protocol of the target selection phase III CHIC-STS trial

Archive ouverte | Filleron, Thomas | CCSD

International audience. Abstract Background The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be p...

Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome

Archive ouverte | Benhaddou, Ataaillah | CCSD

International audience. Genomic instability (GI) influences treatment efficacy and resistance, and an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (S...

Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas

Archive ouverte | Darbo, Elodie | CCSD

International audience. In leiomyosarcoma (LMS), a very aggressive disease, a relatively transcriptionally uniform subgroup of well-differentiated tumors has been described and is associated with poor survival. The ...

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