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Loop extrusion as a mechanism for formation of DNA damage repair foci

Archive ouverte | Arnould, Coline | CCSD

International audience. The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-size...

Loop extrusion as a mechanism for formation of DNA damage repair foci

Archive ouverte | Arnould, Coline | CCSD

International audience. The repair of DNA double-strand breaks (DSBs) is essential for safeguarding genome integrity. When a DSB forms, the PI3K-related ATM kinase rapidly triggers the establishment of megabase-size...

Loop extrusion as a mechanism for DNA Double-Strand Breaks repair foci formation

Archive ouverte | Arnould, Coline | CCSD

DNA Double-Strand Breaks (DSBs) repair is essential to safeguard genome integrity. Upon DSBs, the ATM PI3K kinase rapidly triggers the establishment of megabase-sized, γH2AX-decorated chromatin domains which further act as seeds f...

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