0 avis
Redox-Active Agents in Reactions Involving the Trypanothione/Trypanothione Reductase-based System to Fight Kinetoplastidal Parasites
Archive ouverte
International audience. African trypanosomiasis, Chagas disease, and leishmaniasis are human infectious diseases caused by various kinetoplastid parasites. Trypanothione reductase (TR) is a flavoenzyme unique to these parasites that is responsible for maintaining trypanothione (bis(glutathionyl)spermidine) in its reduced dithiol form. This enzyme plays a crucial role in the thiol redox metabolism and is essential in vivo for all trypanosomatids living in the human host studied so far. These findings make the flavoenzyme a promising target for anti-kinetoplastidal drug development. In this chapter, we examine the work published in the field of redox-active agents acting as substrates of the NADPH-dependent TR-based system. We also highlight our own work on trypanothione-reactive agents and discuss how these compounds might be developed as potential specific lead compounds to fight kinetoplastidal parasites.
Consulter en ligne
Suggestions
Du même auteur
