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Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules.

Archive ouverte | Wasylyk, Christine | CCSD

Net (Elk-3/SAP-2/Erp) is a transcription factor that is phosphorylated and activated by the Ras-extracellular signal-regulated kinase (Erk) signaling pathway and is involved in wound healing, angiogenesis, and tumor growth. In a c...

The transcription factor Net regulates the angiogenic switch

Archive ouverte | Zheng, Hong | CCSD

Angiogenesis is fundamental to physiological and pathological processes. Despite intensive efforts, little is known about the intracellular circuits that regulate angiogenesis. The transcription factor Net is activated by phosphor...

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

Archive ouverte | Sengupta, Sagar | CCSD

The tumour suppressor p53 and the glucocorticoid receptor (GR) respond to different types of stress. We found that dexamethasone-activated endogenous and exogenous GR inhibit p53-dependent functions, including transactivation, up-...

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