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Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

Archive ouverte | Nozaki, Chihiro | CCSD

International audience. Zinc is abundant in the central nervous system and regulates pain, but underlying mechanisms are unknown. In vitro studies have shown that extracellular zinc modulates a plethora of signaling...

Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice

Archive ouverte | Weibel, Raphaël | CCSD

International audience. Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effect...

A novel anxiogenic role for the delta opioid receptor expressed in GABAergic forebrain neurons

Archive ouverte | Chu Sin Chung, Paul | CCSD

International audience. BACKGROUND: The delta opioid receptor (DOR) is broadly expressed throughout the nervous system; it regulates chronic pain, emotional responses, motivation, and memory. Neural circuits underly...

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