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TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression

Archive ouverte | Martianov, Igor | CCSD

Mammalian genomes encode two genes related to the TATA-box binding protein (TBP), TBP-related factors 2 and 3 (TRF2 and TRF3). Male Trf2(-/-) mice are sterile and characterized by arrested spermatogenesis at the transition from la...

Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.

Archive ouverte | Martianov, Igor | CCSD

International audience. BACKGROUND: CREB and CREM are closely related factors that regulate transcription in response to various stress, metabolic and developmental signals. The CREMτ activator isoform is selectivel...

Retinoic acid receptors recognise the mouse genome through binding elements with diverse spacing and topology.

Archive ouverte | Moutier, Emmanuel | CCSD

International audience. Retinoic acid receptors (RARs) heterodimerize with retinoid X receptors (RXRs) and bind to RA response elements (RAREs) in the regulatory regions of their target genes. Although previous stud...

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