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Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism

Archive ouverte | Noll, Christophe | CCSD

International audience. Background and aims: Among cardiovascular risk factor, people with Down syndrome have a lower plasma homocysteine level. In a previous study, we have shown that DYRK1A (dual-specificity tyros...

LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice

Archive ouverte | Latour, Alizee | CCSD

International audience. Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to in...

Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice

Archive ouverte | Noll, Christophe | CCSD

International audience. Hyperhomocysteinemia leads to diverse clinical manifestations, notably liver disease. The pathogenicity of homocysteine is believed to be due to its ability to produce oxidative stress. Parao...

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