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The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

Archive ouverte | Fanfrlík, Jindřich | CCSD

The effect of halogen-to-hydrogen bond substitution on the binding energetics and biological activity of a human aldose reductase inhibitor has been studied using X-ray crystallography, IC50 measurements, advanced binding free ene...

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Archive ouverte | Ruiz Figueras, Francesc Xavier | CCSD

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Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008

Archive ouverte | Ruiz Figueras, Francesc Xavier | CCSD

UVI2008, a retinoic acid receptor (RAR) beta/gamma agonist originated from C3 bromine addition to the parent RAR pan-agonist 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzo ic acid (TTNPB), is als...

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