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Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008

Archive ouverte | Ruiz Figueras, Francesc Xavier | CCSD

UVI2008, a retinoic acid receptor (RAR) beta/gamma agonist originated from C3 bromine addition to the parent RAR pan-agonist 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzo ic acid (TTNPB), is als...

Structural Determinants of the Selectivity of 3‐Benzyluracil‐1‐acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10

Archive ouverte | Ruiz, Francesc | CCSD

International audience. Abstract The human enzymes aldose reductase (AR) and AKR1B10 have been thoroughly explored in terms of their roles in diabetes, inflammatory disorders, and cancer. In this study we identified...

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

Archive ouverte | Giménez-Dejoz, Joan | CCSD

International audience. Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well characterized enzyme with high retina...

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