Suggestions

Du même auteur

Structure-based design of short peptide ligands binding onto the E. coli processivity ring.

Archive ouverte | Wolff, Philippe | CCSD

International audience. The multimeric DNA sliding clamps confer high processivity to replicative DNA polymerases and are also binding platforms for various enzymes involved in DNA metabolism. These enzymes interact...

Interaction of a Model Peptide on Gram Negative and Gram Positive Bacterial Sliding Clamps

Archive ouverte | André, Christophe | CCSD

International audience. Bacterial sliding clamps control the access of DNA polymerases to the replication fork and are appealing molecular targets for antibacterial drugs development. To this end, it is critical to ...

Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp

Archive ouverte | Monsarrat, Clément | CCSD

International audience. The bacterial DNA sliding clamp (SC), or replication processivity factor, is a promising target for the development of novel antibiotics. We report a structure–activity relationship study of ...

Chargement des enrichissements...