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Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

Archive ouverte | Han, Sisu | CCSD

SUMMARY Transition from smooth, lissencephalic brains to highly-folded, gyrencephalic structures is associated with neuronal expansion and breaks in neurogenic symmetry. Here we show that Neurog2 and Ascl1 proneural genes regulate...

Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

Archive ouverte | Han, Sisu | CCSD

International audience. Asymmetric neuronal expansion is thought to drive evolutionary transitions between lissencephalic and gyrencephalic cerebral cortices. We report that Neurog2 and Ascl1 proneural genes togethe...

PAR2-dependent activation of GSK3 beta regulates the survival of colon stem/progenitor cells

Archive ouverte | Nasri, Imen | CCSD

Protease-activated receptors PAR1 and PAR(2) play an important role in the control of epithelial cell proliferation and migration. However, the survival of normal and tumor intestinal stem/progenitor cells promoted by proinflammat...

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