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Conversion of Sox17 into a Pluripotency Reprogramming Factor by Reengineering Its Association with Oct4 on DNA

Archive ouverte | Jauch, Ralf | CCSD

International audience. Abstract Very few proteins are capable to induce pluripotent stem (iPS) cells and their biochemical uniqueness remains unexplained. For example, Sox2 cooperates with other transcription facto...

Sox Transcription Factors Require Selective Interactions with Oct4 and Specific Transactivation Functions to Mediate Reprogramming

Archive ouverte | Aksoy, Irène | CCSD

International audience. Abstract The unique ability of Sox2 to cooperate with Oct4 at selective binding sites in the genome is critical for reprogramming somatic cells into induced pluripotent stem cells (iPSCs). We...

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

Archive ouverte | Aksoy, Irène | CCSD

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