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Muscle wasting in patients with end‐stage renal disease or early‐stage lung cancer: common mechanisms at work

Archive ouverte | Aniort, Julien | CCSD

International audience. Background Loss of muscle mass worsens many diseases such as cancer and renal failure, contributes to the frailty syndrome , and is associated with an increased risk of death. Studies conduct...

Muscle wasting in hemodialysis and lung cancer patients is mediated through down and upregulation of several proteins common to both diseases, including actors of the proteasome and the autophagy proteolytic systems

Archive ouverte | Aniort, Julien | CCSD

International audience. Introduction Muscle atrophy is frequently encountered in diseased patients. It contributes to patient’s frailty and is associated with an increased risk of death. Studies using animal models ...

Knockout of the muscle-specific E3 ligase MuRF1 affects liver lipid metabolism upon dexamethasone treatment in mice

Archive ouverte | Mosoni, Laurent | CCSD

International audience. In order to preserve muscle mass during catabolic states, investigators are actively searching for a specific inhibitor of MuRF1, the only known E3 ligase able to target muscle contractile pr...

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