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Surrogate markers of intestinal dysfunction associated with survival in advanced cancers

Archive ouverte | Birebent, Roxanne | CCSD

International audience. Deviations in the diversity and composition of the gut microbiota are called "gut dysbiosis". They have been linked to various chronic diseases including cancers and resistance to immunothera...

Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Archive ouverte | Derosa, Lisa | CCSD

International audience. Aside from PD-L1 expression, biomarkers of response to immune checkpoint inhibitors (ICIs) in non-small-cell lung cancer (NSCLC) are needed. In a previous retrospective analysis, we documente...

A microbiota-modulated checkpoint directs immunosuppressive intestinal T cells into cancers

Archive ouverte | Fidelle, Marine | CCSD

International audience. Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but the mechanisms underlying their immunosuppressive effects remain unknown. ...

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