Syracuse

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provides insights into risks for potential new cross-species transmissions

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Aghokeng Fobang, Avelin | Ayouba, Ahidjo | Mpoudi-Ngole, Eitel | Loul, Severin | Liégeois, Florian | Delaporte, Eric | Peeters, Martine

Edité par CCSD ; Elsevier -

International audience. HIV-1 and HIV-2, the etiologic agents for AIDS in humans, are the results of cross-species transmissions of lentiviruses from non-human primates (Hahn et al., 2000). The closest simian relatives of HIV-1 are SIVcpz and SIVgor, from chimpanzees (Pan troglodytes troglodytes) and gorillas (Gorilla gorilla gorilla) in West central Africa (Gao et al., 1999; Sharp et al., 2005; Keele et al., 2006; Van Heuverswyn et al., 2006), and HIV-2 is derived from SIVsmm from sooty mangabeys (Cercocebus atys) in West Africa (Hirsch et al., 1989; Gao et al., 1992). SIVsmm has been transmitted to humans at least 8 times in West Africa, and similarly, HIV-1 group M, N and O are each the result of an independent cross-species transmission of SIVs from the SIVcpz/ SIVgor lineage.

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