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OSTEOPOROSIS IS UNCOMMON IN EARLY CLONAL MAST CELL DISORDERS
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Edité par CCSD ; BMJ Publishing Group Ltd and European League Against Rheumatism -
International audience. Background Indolent systemic mastocytosis (ISM) is a hematological disease frequently associated with vertebral osteoporosis (OP) and subsequent vertebral fractures. The natural history of this OP remains unclear. Importantly, we do not know whether OP represents an early event triggered alongside mast cell abnormalities. Experts in the field recently introduced the debated concept of “pre-ISM” to refer to patients with abnormal clonal mast cells and clinical repercussions who do not fulfill the criteria for ISM [1]. These patients can be considered as having an early clonal mast cell disorder (cMCD).Objectives To describe OP in patients with cMCD and to compare osteoporosis characteristics of early cMCD patients to those of ISM patients.Methods We retrospectively analyzed clinical, biological and densitometric data of 40 cMCD and 135 ISM patients from the mastocytosis expert center (CEREMAST) in Toulouse.Data normality was tested by a Shapiro-Wilk normality test. Comparisons between subgroups were performed using: Student’s t-test for the normally distributed data, a non-parametric Wilcoxon rank-sum test for non-normally distributed data, and Fisher’s exact test (or chi-square test if appropriate) for dichotomous variables. A p-value <0.05 was considered statistically significant with a 95% confidence interval (CI).Results OP (12.5 vs 34.1%) and vertebral fractures (5.0 vs 18.5%) were significantly less frequent in the early cMCD population. Most patients with OP and vertebral fractures in the cMCD group had the usual risk factors for OP
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