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Adult Niemann-Pick disease type C in France: clinical phenotypes and long-term miglustat treatment effect

Archive ouverte | Nadjar, Yann | CCSD

International audience. BackgroundNiemann-Pick disease type C (NP-C) is a neurodegenerative lysosomal lipid storage disease caused by autosomal recessive mutations in the NPC1 or NPC2 genes. The clinical presentatio...

Fatigue in de novo Parkinson's Disease: Expanding the Neuropsychiatric Triad?

Archive ouverte | Béreau, Matthieu | CCSD

BACKGROUND: Fatigue is a frequent and troublesome symptom present from the early stages of Parkinson's disease (PD). OBJECTIVE: To examine the relationship between fatigue and the neuropsychiatric triad, which includes apathy, dep...

A randomized controlled double-blind study of rotigotine on neuropsychiatric symptoms in de novo PD

Archive ouverte | Castrioto, Anna | CCSD

Management of apathy, depression and anxiety in Parkinson's disease (PD) represents a challenge. Dopamine agonists have been suggested to be effective. This multicenter, randomized (1:1), double-blind study assessed the 6-month ef...

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