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First Evidence of Candidate Phyla Radiation in Chronic Hepatitis B Virus-Infected Patients: A Case-Control Metagenomic Study
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Edité par CCSD -
Background: Numerous bacterial taxa in the human microbiome have yet to be cultured, such as the CPR superphylum (͠͠ ͠͠ around 25% of bacterial diversity). What we know about CPR is at the genomic level. The role of Candidatus Saccharibacteria in gut microbiota has been described as predominantly anti-inflammatory. However, detection of CPR in HBV infection has not been reported till now. Methodology: Different methods using standard PCR, qPCR, 16S rRNA sequencing, whole genome sequencing, and electron microscopy were used.
Results: Correlation analysis showed a significant negative correlation with the prothrombin index, indicating their role should be further investigated in hepatic diseases through developing specific culture methods. Conclusion: Our study proved for the first time a significant abundance of the CPR phyla, particularly Candidatus Saccharibacteria, in HBVinfected patients.
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