The gut microbiome (microbial community with distinct physio-chemical properties in a given habitat 1 ) → major role in maintaining health.

• Stratification through the gastrointestinal tract (micro-organisms and metabolites) (Figure 1).

• Dysbiosis = unbalanced microbiome → linked to some cancers, inflammatory, metabolic and neurological diseases… • Current methods for the study of the human intestinal microbiome: not representative of the entire gut microbiome.

• Faecal analysis: common but do not fully represent the intestinal microbiome (only large bowel).

• Endoscopy and colonoscopy: expensive, invasive and complex to implement on a large scale. Could introduce a contamination bias during collection 2 .

To overcome these issues, PELICAN HEALTH develops a cutting-edge ingestible device, able to perform multi-sampling in the small intestine (SI) to perform multi-omics analysis (Figure 2).