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Symplekin, a polyadenylation factor, prevents MOZ and MLL activity on HOXA9 in hematopoietic cells

Archive ouverte | Largeot, Anne | CCSD

International audience. MOZ and MLL encoding a histone acetyltransferase and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblast...

Trim33/Tif1γ is involved in late stages of granulomonopoiesis in mice.

Archive ouverte | Chrétien, Marie-Lorraine | CCSD

IF 2.303 . International audience. Trim33/Tif1γ (Trim33) is a member of the tripartite motif family. Using a conditional hematopoietic-specific Trim33 knock-out (Trim33(Δ/Δ)) mouse, we showed previously that Trim33 ...

Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia

Archive ouverte | Sauter, Camille | CCSD

International audience. Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer development. PRMT2 expression is increased in ...

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