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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Archive ouverte | Souchet, Benoît | CCSD

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Increased Dosage of DYRK1A and Brain Volumetric Alterations in a YAC Model of Partial Trisomy 21.

Archive ouverte | Sebrié, Catherine | CCSD

International audience. A yeast artificial chromosome (YAC) transgenic murine model of partial trisomy 21 overexpressing five human genes-including DYRK1A, which encodes a serine threonine kinase involved in cell cy...

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models

Archive ouverte | Souchet, Benoit | CCSD

International audience. Cognitive impairment in Down syndrome (DS) has been linked to increased synaptic inhibition. The underlying mechanisms remain unknown, but memory deficits are rescued in DS mouse models by dr...

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