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Why mitochondria must fuse to maintain their genome integrity

Archive ouverte | Vidoni, Sara | CCSD

International audience. SIGNIFICANCE: The maintenance of mitochondrial genome integrity is a major challenge for cells to sustain energy production by respiration.RECENT ADVANCES: Recently, mitochondrial membrane dy...

OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution

Archive ouverte | Elachouri, Ghizlane | CCSD

International audience. Eukaryotic cells harbor a small multiploid mitochondrial genome, organized in nucleoids spread within the mitochondrial network. Maintenance and distribution of mitochondrial DNA (mtDNA) are ...

OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes.

Archive ouverte | Amati-Bonneau, Patrizia | CCSD

International audience. Mutations in OPA1, a dynamin-related GTPase involved in mitochondrial fusion, cristae organization and control of apoptosis, have been linked to non-syndromic optic neuropathy transmitted as ...

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